UPDATING GLOBAL ESTIMATES OF PATHOGEN-ATTRIBUTABLE DIARRHOEAL DISEASE BURDEN: A METHODOLOGY AND INTEGRATED PROTOCOL FOR A BROAD-SCOPE SYSTEMATIC REVIEW OF A SYNDROME WITH DIVERSE INFECTIOUS AETIOLOGIES

Updating global estimates of pathogen-attributable diarrhoeal disease burden: a methodology and integrated protocol for a broad-scope systematic review of a syndrome with diverse infectious aetiologies

Introduction Sustaining declines in global infectious disease burden will increasingly require efforts targeted to specific aetiological agents and common transmission pathways, particularly in this era of global change and human interconnectivity accelerating transmission and emergence of infectious pathogens.Systematic reviews and meta-analyses c

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Maternal smoking during pregnancy increases the risk of gut microbiome-associated childhood overweight and obesity

ABSTRACTChildhood obesity is linked to maternal smoking during pregnancy.Gut microbiota may partially mediate this association and could be potential targets for intervention; however, its role is understudied.We included 1,592 infants from the Canadian Healthy Infants Longitudinal Development Cohort.Data on environmental exposure and lifestyle fac

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Pars plana vitrectomy for vitreoretinal interface disorders coincident with intermediate stage age-related macular degeneration

Background and Aims.Currently around 67 Dice million people in Europe are affected by some form of age-related macular degeneration (AMD).As most known types of vitreoretinal (VR) interface disorders can coexist with AMD and as we can favourably affect the former with vitreoretinal surgery, our goal was to evaluate the results of vitreoretinal inte

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